16 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
100-500): • NAFLD ... 1000): • DILI (Drug-induced ... liver injury) ... • Ischemic Hepatopathy ... Differential #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... /Toxins • Ischemia ... ALT < 5x ULN • NAFLD ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... valproate, azoles), Drugs ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #LFTs #hepatitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... 15X ULN - Drugs ... , Viral, Ischemia ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... Injury Transaminase ... #Patterns #Liver ... #Injury #hepatology ... #LFTs #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... gastroenterology #algorithm ... gastroenterology #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
of Severe Acute Liver ... Injury - Ichemic ... obstruction - Drug-Induced ... liver injury ... #Differential #Hepatology
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypothyroid • Liver ... • Alcohol • Drugs ... #Macrocytic #Anemia ... differential #diagnosis #algorithm ... #hematology #workup
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Injury (DILI) - ... Stepwise Diagnosis Algorithm ... disease, Hepatic ischaemia ... #Algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... , Recreational Drugs ... Antitrypsin • Other: NAFLD ... Causes #Acute #algorithm ... #hepatology