14 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Differential Diagnosis ... 100-500): • NAFLD ... (>1000): • DILI ... injury) • Ischemic ... Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Injury (DILI) ... Chronic - ongoing ↑ LFTs ... #differential # ... gastroenterology #algorithm ... gastroenterology #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... : Liver Injury ... Injury Differential ... #Injury #Differential ... #Diagnosis #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 20x normal - Acute ... #Injury #hepatology ... #LFTs #transaminitis ... #differential # ... diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Algorithm DILI ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... • Others #LFTs ... Diagnosis #Algorithm
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Diagnosis Algorithm ... Drugs, Viral, Ischemia ... #diagnosis #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Liver Injury ... - Ichemic hepatitis ... injury - Viral ... #Causes #Differential ... #Hepatology #Diagnosis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... Diagnosis: Viral ... #hepatology #obstetrics
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... diagnosis #algorithm ... #hepatology