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liver transaminitis management hepatitis abnormal causes chemistry drug druginduced elevated function gastroenterology hepatocellular idiosyncratic induced interpretation liverenzymes liverfunctiontests patterns prs
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
) - Differential ... (>1000): • DILI ... Drug-induced liver injury ... ) • Ischemic Hepatopathy ... Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Diagnosis Algorithm ... non-essential drug/HDS treatments ... disease, Hepatic ischaemia ... #Diagnosis #Algorithm ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... Patterns #Liver #Injury ... #hepatology #LFTs ... transaminitis #differential ... #diagnosis
Bradycardia Diagnostic and Management Algorithm CONSIDER ETIOLOGY (not inclusive): - STRUCTURAL: sick sinus, AV block, ischemia,
Bradycardia Diagnostic ... and Management Algorithm ... sinus, AV block, ischemia ... THREATENING CAUSES & TREATMENT ... #Algorithm #Differential
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Differential Diagnosis ... • Vascular: Ischemic ... Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... • Others #LFTs ... #Hepatology #LiverEnzymes ... Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... #hepatitis #differential ... #diagnosis #algorithm ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Diagnosis Algorithm ... Drugs, Viral, Ischemia ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis ... #LFTs #RValue #
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