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Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
- Differential ... neutrophil count < 500 cells ... Superior Vena Cava ... Hypercalcemia ... #differential #
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... - Seizures - Malignant ... - Neuroleptic malignant ... perfusion → renal ischemia ... kidney tubular cells
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Redistribution: Acidosis, Cell ... /crush injury, ischemia ... reabsorption) Workup ... Drives K+ into cells ... ileus/obstruction (ischemia
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... high LDH, low Ca ... “big & sticky” cells ... plasmapheresis Hypercalcemia ... of malignancy:
Malignant Hyperthermia Crisis - Guidelines for Crises in Anaesthesia
Unexplained increase in ETCO2 AND tachycardia AND increased
Malignant Hyperthermia ... for MH treatment ... , invasive BP, CVP ... with dantrolene Hyperkalaemia ... Diagnosis #Management #Workup
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
& colon malignancy ... pancreatic islet cell ... Differential Diagnosis ... Diagnosis and Workup ... Endocrinology #Treatment
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hematological malignancy ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... Hodgkin Lymphoma Treatment ... classification #hematology #oncology
Ear Pain (Otalgia) - Differential Diagnosis Framework

Primary Otalgia 
 - Pain that originates from the ear
Pain (Otalgia) - Differential ... myringitis • Malignant ... Basal/squamous cell ... CA • Melanoma ... • Myocardial ischemia
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
which all carry treatment ... hormones that work ... Pyruvate to Acetyl-CoA ... #diagnosis #differential ... #algorithm #management
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
CRAB - no anemia, hypercalcemia ... + diff • CMP, Ca ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... #Diagnosis #Workup