35 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... #Patterns #Liver ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - ... Differential Diagnosis ... injury) • Ischemic ... #Differential # ... Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... Drugs/Toxins • Ischemia ... hepatitis • Drugs ... • Others #LFTs
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... of Alcoholic Hepatitis ... factors • Possible ischemic ... hepatitis (e.g. ... #hepatology #criteria
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... #Diagnosis #hepatology ... Transaminitis #LFTs ... #hepatitis
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
) • Advanced Liver ... Disease - Alcohol ... , Viral hepatitis ... Malignancy, Autoimmune disorders ... comparison #diagnosis #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
HEV, EBV, CMV), Alcohol-related ... Hepatic ischaemia ... Hepatic vascular disorder ... Chronic hepatitis ... • Autoimmune hepatitis
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... factors - Possible ischemic ... hepatitis (e.g. ... ) or metabolic liver ... #Diagnosis #Hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... for HIV, HCV - Alcohol ... gastric bypass), LFT ... (liver disease) ... Causes #Workup #hematology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Drugs, Viral, Ischemia ... - NAFLD, Alcohol ... Burak @kwburak #LFTs