16 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... CNS #neurology #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Causes of Splenomegaly ... - Differential ... Inflammatory • Systemic Lupus ... Spleen #Enlarged #Differential ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... . lupus, CLL, lymphoma ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Post-strep GN, Lupus ... involvement: Anti-GBM Disease ... diagnosis #algorithm #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... lymphoproliferative syndrome Clinical ... Erythematosus #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
: • Purpura, ischemic ... tract, and often causes ... Kidneys: glomerular ischemia ... such as systemic lupus ... #diagnosis #rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Arterial Thrombosis - Differential ... Myeloproliferative disease ... Nephrotic Syndrome, Ischemic ... Venous #Arterial #pathophysiology ... #hematology #differential
Bradycardia - Differential Diagnosis 
 • Cardiac disease: Myocardial ischemia / infarction, Myocarditis, Congenital disorders, Cardiomyopathies,
Bradycardia - Differential ... Diagnosis • Cardiac disease ... : Myocardial ischemia ... . systemic lupus ... Physiological causes
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... , - regional ischemia ... of lactate as a clinical ... presentations and disease ... Acidosis #Elevation #Differential
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
cryoglobulin (CG ... limb and bowel ischemia ... Diagnosis: • + Clinical ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology