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Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Clinical features ... Noncontiguous spread • Clinical ... involvement Differential ... oncology #diagnosis #differential ... #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Lymphoma - Clinical ... Weight loss • Anemia ... Immunohistochemical studies (to differentiate ... number of sites of disease ... Lymphoma Treatment
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... anemia (sometimes ... Chemotherapy (e.g ... RBC #Morphology #differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... Orange or Hep C Clinical ... cells can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment
Treatments for Sickle Cell disease

#Sicklecell #sicklecelldisease #sicklecellanemia, #sicklecells #sickle #hematology #anemia #clinical #pediatrics #FOAM #FOAMed
Treatments for Sickle ... Cell disease ... sicklecells #sickle #hematology ... #anemia #clinical
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
. lupus, CLL, lymphoma ... . sickle cell disease ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
(e.g. ... cells: Sickle cell ... disease Bite cells ... Smear #Analysis #hematology ... interpretation #clinical
Diffuse Acute Abdominal Pain (<72 hours) - Differential Diagnostic Algorithm
Look for surgical abdomen
Upper quadrant: R/O cardiac,
(<72 hours) - Differential ... • Mesenteric ischemia ... (e.g., Diabetic ... Ketoacidosis) • Sickle cell ... anemia • Musculoskeletal
Vascular Joint Pain - Differential Diagnosis Algorithm 
 - Constant Pain (Ischemia)
 - Acute Onset
 -
Vascular Joint Pain - Differential ... Constant Pain (Ischemia ... Occlusion • Sickle Cell ... Anemia • Peripheral ... Vascular Disease
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Chronic kidney disease ... infiltration (e.g ... . sickle cell anemia ... Production #Index #hematology ... #anemia #differential