51 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... of disease and ... organs leading to ischemia ... SickleCell #Disease #Pathophysiology ... Complications #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Bleeding / Bruising - Differential ... Rare • Drugs (e.g ... ASA) • Renal Disease ... Bleeding #Bruising #Differential ... Algorithm #Causes #Hematology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Syndrome - Diagnosis and ... Lymphoproliferative disorders (e.g ... cancer cells (and ... Management #treatment #hematology ... #differential
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
• Mechanism: ischemic ... XR, MRI to dx and ... • Differentiate ... SickleCell #Disease #differential ... diagnosis #causes #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... (e.g., SLE), anti-phospholipid ... (CVID, WAS), (neurologic ... or if a primary hematologic ... Causes #Workup #hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... and laboratory ... characterized by an ... count, D-dimer, egg ... hemolytic #anemia #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... disease, Copper and ... Extravascular #Causes #differential ... #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... AKI, acute limb ischemia ... Lysis Syndrome: • Pathophysiology ... unless worrisome EKG ... diagnosis #management #hematology