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diagnosis hematology differential abnormal prolonged syndrome vasculitis workup activation bleeding bone bruising child classification coagulation cryofibrinogenemia enlarged evaluation ferritin glomerular
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
: Is the PT or APTT ... ) Step 3: Is a Systemic ... Disease Prolonging ... to identify the cause ... prolonged #diagnosis #hematology
Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
Diagnostic Schema ... Still's disease ... Systemic histoplasmosis ... Hyperferritinemia #Algorithm ... Differential #Diagnosis #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Causes of Splenomegaly ... Differential Diagnosis Algorithm ... Inflammatory • Systemic ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Vascular System ... TeIangiectasia Vascular System ... #Causes #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Pre-analytical cause ... associated with systemic ... #differential #hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
FLAGS - In all cases ... guidelines General - Systemic ... Haematology - ... Rheumatology ... #Limping #NWB #Algorithm
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Cell Disease Vaso-occlusive ... : ischemic pain ... #SickleCell #Disease ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
highly inflammatory disease ... • Fever is the main ... Hypofibrinogenemia • ↑ PT ↑ PTT ... Diagnosis #Management #Hematology ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Purpura, ischemic ... tract, and often causes ... Kidneys: glomerular ischemia ... , testes -> pain ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis: • Purpura, ischemic ... and mesenteric ischemia ... tract: Abdominal pain ... tract, and often causes ... Differential #Diagnosis #Rheumatology
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