22 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... ischemia and/or ... cyclophosphamide • Ischemic ... CNS #neurology #rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... visual changes, stroke ... AKI, acute limb ischemia ... diagnosis #management #hematology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Heat iniury, Heat stroke ... Dermatomyositis) AKI - Pathophysiology ... decreased renal renal ischemia ... Management #Summary #causes ... #treatment
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... organs leading to ischemia ... SickleCell #Disease #Pathophysiology ... Complications #Hematology
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism

In contrast to the
from Myocardial Ischemia ... from myocardial ischemia ... associated with rheumatologic ... life-threatening causes ... #Presentation #comparison
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... • Mechanism: ischemic ... differential #diagnosis #causes ... #hematology
Treatment of giant cell arteritis (GCA)

1st Line Strategy - GC 0.7 mg/kg/day, except for:
 • Aortitis
Treatment of giant ... mg/kg/day • Ischemic ... scalp necrosis, stroke ... MTX or TCZ in case ... #Indications #rheumatology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
without other cause ... : 33% • Treatment ... : No • Treatment ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Nephrotic Syndrome, Ischemic ... considered in all cases ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
normal in mild cases ... by a hemophilia treatment ... Eric Strong @DrEricStrong ... - Strong Medicine ... #hematology