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diagnosis differential liver transaminitis thrombosis vasculitis abnormal arterial cryoglobulinemia cryoglobulins dili druginduced elevated embolism function hematology hepatitis hepatocellular liverenzymes liverfunctiontests
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... CMV), Alcoholic cirrhosis ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... #hepatology #LFTs
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... • NAFLD • Cirrhosis ... Drug-induced liver injury ... ) • Ischemic Hepatopathy ... Differential #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Causes
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... Drugs, Viral, Ischemia ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver Injury ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Portal Vein Thrombosis (PVT) Treatment Algorithm - If concern for ischemic: anti-coag+multidisciplinary care - W/o cirrhosis+recent
PVT) Treatment Algorithm ... If concern for ischemic ... anti-thrombotic tx - Cirrhosis ... : case-by-cased ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... disease, Hepatic ischaemia ... #Diagnosis #Algorithm ... #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Nephrotic Syndrome, Ischemic ... considered in all cases ... coagulation and other causes ... Vasculitis • Injury ... pathophysiology #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
causing endothelial injury ... • They can cause ... - (Ischemia, ... diagnosis #types #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Purpura, ischemic ... tract, and often causes ... Kidneys: glomerular ischemia ... Tests: • CBC • LFT ... #classification
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