26 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... CMV), Alcoholic cirrhosis ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... #LFTs #transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Function Tests (LFTs ... • NAFLD • Cirrhosis ... liver injury) • Ischemic ... Function #Tests #LFTs ... Differential #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Drugs/Toxins • Ischemia ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Drugs, Viral, Ischemia ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... Rapid onset of symptoms ... Signs / Symptoms ... e.g. arrythmias, ischemia ... #Anaphylaxis #pathophysiology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Vascular: Ischemic ... Differential #Diagnosis #hepatology ... Transaminitis #LFTs
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... organs leading to ischemia ... SickleCell #Disease #Pathophysiology ... Complications #Hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... AKI, acute limb ischemia ... Lysis Syndrome: • Pathophysiology ... diagnosis #management #hematology
Acute limb ischemia (ALI)

Rapid decrease in lower limb blood flow due to acute occlusion of peripheral
Acute limb ischemia ... The symptoms of ... exacerbation of ischemia ... Critical Limb ischemia ... pathophysiology:
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
causes fluffy white ischemic ... Elschnig's Spots • Ischemia ... #Retinopathy #pathophysiology ... diagnosis #signs #symptoms