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causes lfts algorithm radiology transaminitis appearance hepatic lesions abnormal classification elevated hematology injury management pathophysiology pocus rheumatology symptoms ultrasound vasculitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... AST:ALT = 1 - Ischemia ... , Ischemic Necrosis ... #Injury #hepatology ... #diagnosis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
of Severe Acute Liver ... Injury - Ichemic ... - Drug-Induced liver ... Acute #Causes #Differential ... #Hepatology #Diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... Diagnosis Framework ... Chronic Viral Hepatitis ... injury) • Ischemic ... #Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Diagnosis Framework ... Infections: Hepatitis ... • Vascular: Ischemic ... #Diagnosis #hepatology ... Transaminitis #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminitis - Differential ... Diagnosis • ... Trauma: Shock liver ... See Updated Schema ... #hepatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... factors - Possible ischemic ... ) or metabolic liver ... Possible drug-induced liver ... #Diagnosis #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... factors • Possible ischemic ... ) or metabolic liver ... #diagnosis #Alcoholic ... #hepatology #criteria
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Diagnosis Framework ... RBCs, muscle, liver ... • Ischemic hepatitis ... distinguishes ischemic ... injury • Demand ischemia
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... disease, Hepatic ischaemia ... • Autoimmune hepatitis ... #Injury #Diagnosis ... #Algorithm #hepatology
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