16 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... #hepatology #LFTs ... #transaminitis
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Transaminases / Transaminitis ... HAV, HCV, HEV, EBV ... Metabolic: Wilson Disease ... See Updated Schema ... Diagnosis #causes #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatitis A/B/C/D/E, EBV ... • Vascular: Ischemic ... HELLP, Celiac disease ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Drug-induced liver injury ... ) • Ischemic Hepatopathy ... Differential #Diagnosis #hepatology ... #transaminitis
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Severe Acute Liver Injury ... - Ichemic hepatitis ... Drug-Induced liver injury ... hepatitis - Wilson disease ... #Differential #Hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Algorithm for Transaminitis ... Drugs, Viral, Ischemia ... , Pancreatic CA, ... Elevated #Abnormal #Transaminitis ... Algorithm #diagnosis #hepatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... that will cause ischemia ... cyclophosphamide • Ischemic ... prevention (statin for CVA ... cerebritis #diagnosis #management
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Induced Liver Injury ... HBV, HCV, HEV, EBV ... Alcohol-related liver disease ... , Hepatic ischaemia ... Diagnosis #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Venoocclusive disease ... HBV, HCV, HEV, EBV ... : Often breast CA ... small cell lung CA ... diagnosis #algorithm #hepatology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... perfusion → renal ischemia ... of underlying disease ... Differential #Diagnosis #Management ... causes #treatment #nephrology