9 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... • Cholestatic DILI ... #Management #gastroenterology ... #algorithm #gastroenterology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
abnormality vs bone Bili ... injury >2 ... injury Sinai ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Algorithm Vascular ... specificity to elevated ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... : Liver Injury ... Liver Injury Differential ... #Liver #Injury ... #hepatology #algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Algorithm DILI ... titres, ↑ IgG • Cholestatic ... #Injury #Diagnosis ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
ALP) • R > 5: Hepatocellular ... specificity to elevated ... #chemistry #diagnosis ... #differential #Hepatology ... #transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Algorithm for Transaminitis ... Hepatocellular ... kwburak #LFTs #Elevated ... #Algorithm #diagnosis
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
Algorithm regarding ... the diagnosis and ... screening for hepatocellular ... #diagnosis #management ... #hepatology #gastroenterology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
- Typically hepatocellular ... injury, though ... cholestatic pattern ... IgG typically elevated ... #Management #Hepatology