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pain approach hodgkins leukemia lymphoma management msk algorithm apml causes chronic classification cll conditions differentiation diffuse extrarticular gap globulin lad
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... • Rheumatoid Arthritis ... Fatigue • Acute ... #Causes #Hematology ... #Oncology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Bacterial or viral infection ... - Gout • Jaundice ... Lymphadenopathy ... #pain #differential ... #diagnosis #rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... #rheumatology # ... approach #workup ... #differential # ... diagnosis #arthritis
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
Acute or chronic ... #Pain #MSK #rheumatology ... #approach #workup ... #differential # ... diagnosis #arthritis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
e.g., HIV), EBV infection ... disease: B symptoms, lymphadenopathy ... #oncology #diagnosis ... #differential # ... hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... bone pain, fever, joint ... pain, bleeding, infections ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Imaging: CXR- pulmonary ... initiation • Differential ... Diagnosis: Infection ... #management #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... phenomenon CLL Diagnosis ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... Presentation: • Lymphadenopathy ... Hodgkin Lymphoma Workup ... classification #hematology ... #oncology #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Include: • Viral infections ... (RA, Temporal arteritis ... gastric tumors • Hematology ... #diagnosis #hematology
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