23 results
Thrombocytopenia 
Work up, differential diagnosis and management.

Satyendra Dhar MD, @DharSaty

#thrombocytopenia #platelets #ITP #DIC
Thrombocytopenia ... Work up, differential ... diagnosis and management ... @DharSaty #thrombocytopenia ... platelets #ITP #DIC
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... • TTP/HUS • DIC ... #Differential # ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... Platelet Disorders - Differential ... Diagnosis and Workup ... Platelet #Disorders #Differential ... #Workup #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential ... Microangiopathy: DIC ... #Differential # ... Diagnosis #Framework #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... inflammation • Thrombocytopenia ... : - Thrombocytopenia ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Schistocytes, thrombocytopenia ... - DIC, TTP, HELLP ... Diagnosis #Algorithm #workup ... #hematology #testing
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... rapidly develops (DIC ... , ascites, jaundice ... infiltration) Differential ... Liver #Pregnancy #hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation (DIC ... microangiopathy: Thrombotic thrombocytopenic ... #differential # ... diagnosis #hematology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Pruritus, Mild jaundice ... features: Hemolysis, Thrombocytopenia ... DIC • Aminotransferases ... Disease #Pregnancy #hepatology ... hepatitis #comparison #differential