12 results
diagnosis differential liver algorithm causes chemistry cirrhosis hyperbilirubinemia interpretation laboratory management pbc primary tests treatment acute alkphos astalt bilirubinemia calling
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... drug reactions) Conjugated ... postoperative jaundice ... neoplasms #Jaundice ... Classification #diagnosis #conjugated
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... II) Hepatic - Conjugated ... on Ultrasound Biliary ... Gallstones • Biliary ... Algorithm #Causes #Hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... #hepatology #diagnosis ... #gastroenterology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Function Tests (LFTs ... (GGT) - Liver, biliary ... (Conjugated/DBili ... ) - Biliary obstruction ... Interpretation #diagnosis #hepatology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Approach to Conjugated ... elevation + >20% conjugated ... Hyperbilirubinemia #direct #bilirubin ... Diagnosis #Algorithm #gastroenterology ... #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... cytochromes) • Unconjugated ... MRP2 transports conjugated ... #Hepatology #Pathophysiology ... #Diagnosis #LFTs
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
Important findings: jaundice ... - Vitals - LFTs ... Calling #Referral #Hepatology ... #Gastroenterology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... hyperpigmentation • Jaundice ... slightly elevated • Bilirubin ... No extrahepatic biliary ... diagnosis #workup #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... week • Direct bilirubin ... blood cells Unconjugated ... #differential #Hepatology ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Extrahepatic - Biliary ... - Obstruction: Biliary ... week • Direct bilirubin ... injury: ~ 1 Unconjugated ... diagnosis #algorithm #hepatology
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