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diagnosis differential hepatology causes algorithm management ascites lfts physicalexam rheumatology transaminitis abnormal clinical elevated gastroenterology injury pain saag treatment acute
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... hepatocyte damage (eg, hepatitis ... , hepatic cirrhosis ... cirrhosis, sepsis ... postoperative jaundice
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... congenital - Primary biliary ... Nonalcoholic fatty liver ... disease (Budd-Chiari syndrome
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 Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
and hepatorenal syndrome ... • Budd Chiari syndrome ... /acute hepatitis ... sarcoidosis) • Liver ... pregnancy • Primary biliary
Clinical Examination for Liver and Biliary Diseases 1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Examination for Liver ... and Biliary Diseases ... Xanthelasma and jaundiced ... #physicalexam #cirrhosis ... #liver #disease
Ascites - Differential Diagnosis Chronic liver disease (cirrhosis or chronic hepatitis) - 80% Underlying malignancy - 10% Congestive heart
Diagnosis Chronic liver ... disease (cirrhosis ... or chronic hepatitis ... Fitz-Hugh-Curtis syndrome ... Failure, Pancreatic, Biliary
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Non-Malignant • Fatty Liver ... • Budd-Chiari Syndrome ... Infectious • Hepatitis ... Cholangitis • Primary Biliary ... Cirrhosis #Hepatomegaly
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... , Toxic Hepatitis ... CMV), Alcoholic cirrhosis ... , Portal Vein Thrombosis ... #Patterns #Liver
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... /Liver failure ... hyperpigmentation • Jaundice ... or higher • Liver ... Diagnosis: • Viral hepatitis
Right Upper Quadrant Pain Liver: - Infectious: Acute viral hepatitis, Liver abscess - Non-infectious: hepatitis (Alcohol, Medications),
Quadrant Pain Liver ... , Liver abscess ... Non-infectious: hepatitis ... ), Budd-Chiari syndrome ... "biliary colic")
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... • Gilbert's Syndrome ... Crigler-Najjar Syndromes ... Dilatation on Ultrasound ... Gallstones • Biliary
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