31 results
diagnosis hepatology differential algorithm cirrhosis causes hepatitis laboratory lfts metabolism pbc hyperbilirubinemia management primary tests aflp chemistry comparison congenital disease
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
- Pathophysiology ... • Conjugated ... Bilirubin • Unconjugated ... #Metabolism #Pathophysiology ... #hepatology #Liver
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... drug reactions) Conjugated ... conjugates (eg, ... postoperative jaundice ... neoplasms #Jaundice
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
→ Biliverdin → Unconjugated ... Conjugation → Conjugated ... common bile duct Unconjugated ... , and conjugated ... Biochemistry #Metabolism #pathophysiology
Liver Function Tests (LFTs) - Aspartate aminotransferase (AST) - Alanine aminotransferase (ALT) - Alkaline
Liver Function Tests ... transpeptidase (GGT) - Bilirubin ... - Unconjugated ... Indirect) - Conjugated ... Prothrombin #Liver
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
of hemolysis or liver ... breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... an increase in conjugated
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
, biliary epithelium ... (Conjugated/DBili ... ) - Biliary obstruction ... Indirect bilirubin ... (Unconjugated)
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... II) Hepatic - Conjugated ... on Ultrasound Biliary ... Gallstones • Biliary ... Cholangitis #Jaundice
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... cytochromes) • Unconjugated ... MRP2 transports conjugated ... bilirubin into ... #Hepatology #Pathophysiology
Jaundice - Pathophysiology and Causes - Amy Chung, MD, MSc @AmyChung #Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... @AmyChung #Jaundice ... #Pathophysiology ... #Differential #Unconjugated
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Approach to Conjugated ... elevation + >20% conjugated ... MRCP, ERCP, liver ... MatthewHoMD #Conjugated ... Hyperbilirubinemia #direct #bilirubin
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