13 results
Algorithm and Differential Diagnosis of Hyperbilirubinemia 
Direct = Conjugated
Indirect = Unconjugated

#Diagnosis #Jaundice #Hyperbilirubinemia #Differential #Algorithm #Direct
Algorithm and Differential ... = Conjugated Indirect ... #Diagnosis #Jaundice ... #Differential #Algorithm ... #Conjugated #Unconjugated
Jaundice Evaluation Algorithm #Diagnosis #Management #EM #IM #GI #Jaundice #Hyperbilirubinemia #Workup #Evaluation #Differential #Algorithm #Direct #Indirect
Jaundice Evaluation ... Algorithm #Diagnosis ... #Differential #Algorithm ... #Direct #Indirect ... #Conjugated #Unconjugated
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
"indirect bilirubin ... Conjugation → Conjugated ... and "indirect" ... and "direct" bilirubin ... Biochemistry #Metabolism #pathophysiology
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... (predominantly indirect ... drug reactions) Conjugated ... (predominantly direct ... postoperative jaundice
Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... @AmyChung #Jaundice ... #Pathophysiology ... #Differential #Unconjugated
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... Diagnosis Algorithm ... II) Hepatic - Conjugated ... Cholangitis #Jaundice ... Differential #Diagnosis #Algorithm
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... the blood • Defect ... predominantly a mixed conjugated
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
Approach to Conjugated ... Differential Diagnosis Algorithm ... elevation + >20% conjugated ... Hyperbilirubinemia #direct ... Differential #Diagnosis #Algorithm
Bleeding and Bruising - Differential Diagnosis Algorithm
 • Vascular System Defect - Congenital vs Acquired
 •
Differential Diagnosis Algorithm ... Vascular System Defect ... Acquired • Platelet Defect ... Differential #Diagnosis #Algorithm ... #pathophysiology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Differential Diagnosis Algorithm ... • ↑ LDH • ↑ Indirect ... / unconjugated ... Differential #Diagnosis #Algorithm