37 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism - Pathophysiology ... • Conjugated ... Bilirubin • Unconjugated ... Bilirubin #Metabolism #Pathophysiology ... #hepatology #Liver
Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... @AmyChung #Jaundice ... #Pathophysiology ... #Differential #Unconjugated
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... Pre-Hepatic - Unconjugated ... II) Hepatic - Conjugated ... Cholangitis #Jaundice ... Algorithm #Causes #Hepatology
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
→ Biliverdin → Unconjugated ... Conjugation → Conjugated ... bilirubin, and conjugated ... Biochemistry #Metabolism #pathophysiology ... #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... • Increase in conjugated ... Congenital #bilirubin #hepatology
Hemolytic anemia in Wilson's disease

#Wilsons #Disease #hemolytic #anemia #Hematology #pathophysiology
anemia in Wilson's disease ... #Wilsons #Disease ... hemolytic #anemia #Hematology ... #pathophysiology
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver Disease ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Inherited forms of Hyperbilirubinemia
Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
for transporting unconjugated ... Decreased MRP2 - Conjugated ... Decreased OATP1B - Conjugated ... Hyperbilirubinemia #pathophysiology ... #congenital #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
cytochromes) • Unconjugated ... MRP2 transports conjugated ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
) • Onset of jaundice ... before the onset of jaundice ... metabolic liver disease ... (Wilson disease ... Hepatitis #AH #hepatology