56 results
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Liver and Biliary Diseases ... erythema 2) Face: Jaundice ... Xanthelasma and jaundiced ... #physicalexam #cirrhosis ... #liver #disease
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... , hepatitis, hepatic ... cirrhosis) Intrahepatic ... drugs, biliary cirrhosis ... postoperative jaundice
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Etiologies of Cirrhosis ... Inflammation - Hepatitis ... 15 percent) - Hepatitis ... - Wilson disease ... Venoocclusive disease
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
those with CLD (± cirrhosis ... underlying liver disease ... (DILI) Viral Hepatitis ... Liver #Failure #Cirrhosis ... #Hepatology #gastroenterology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
diagnosis of Alcoholic Hepatitis ... ) • Onset of jaundice ... before the onset of jaundice ... metabolic liver disease ... (Wilson disease
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
of Autoimmune Hepatitis ... - Onset of jaundice ... before the onset of jaundice ... metabolic liver disease ... (Wilson disease
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hemochromatosis • Wilson's Disease ... Infectious • Hepatitis ... • Alcoholic Hepatitis ... • Drug Induced Hepatitis ... Primary Biliary Cirrhosis
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... SLE, autoimmune hepatitis ... ) - Autoimmune hepatitis ... Primary biliary cirrhosis ... (TTG) - Celiac disease
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Chronic liver disease ... (cirrhosis or chronic ... hepatitis) - 80% ... failure - 3-5% Cirrhosis ... HIV-related, Renal Disease
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary Cirrhosis ... cholestasis → Cirrhosis ... hyperpigmentation • Jaundice ... but elevated as disease ... Diagnosis: • Viral hepatitis