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An Approach to Jaundice Workup Algorithm by CBC and LFT Pattern

- Dr. Eric Strong @DrEricStrong

#Jaundice #Workup
An Approach to Jaundice ... Algorithm by CBC and LFT ... DrEricStrong #Jaundice ... Algorithm #Patterns #LFTs ... Diagnosis #Hepatology #Differential
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Transaminitis - Differential ... , HCV, HEV, EBV, ... • Autoimmune hepatitis ... Transaminases #hepatitis ... #Differential #
Differential Diagnosis of Jaundice, Presentation Pattern #Diagnosis #EM #IM #GI #Jaundice #Pattern #LFTs #Workup #Table #Differential
Differential Diagnosis ... of Jaundice, Presentation ... Diagnosis #EM #IM #GI #Jaundice ... #Pattern #LFTs ... Workup #Table #Differential
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
- Acute Viral Hepatitis ... , Toxic Hepatitis ... normal - Infection (EBV ... Injury #hepatology #LFTs ... transaminitis #differential
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Function Tests (LFTs ... ) - Differential ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... #Differential #
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Liver Injury - Differential ... • Infections: Hepatitis ... A/B/C/D/E, EBV, ... Transaminitis #LFTs ... #hepatitis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... • Infectious: Hepatitis ... C, A, E, B, D, EBV ... , CMV, HSV • Toxic ... Liver #Injury #Differential
Fever in Returning Travelers from Tropical Regions - Frequent Differential Diagnoses
Medical History:
 • Skin exposure to
Regions - Frequent Differential ... B, hepatitis C ... , hepatitis B and ... plague, anthrax • Jaundice ... Returning #Traveler #differential
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... borrelia, Rubeola, HBV ... Coxsackie, CMV, EBV ... , HIV, HTLVI, Hantavirus ... hepatomegaly, hepatitis
Travel History - Clues to Infectious Disease Diagnosis in a Traveler 
 • Where did you
Hepatitis B, Hepatitis ... C, HIV • Medical ... new partner → HSV ... , HIV, Hepatitis ... InfectiousDiseases #Infections #differential