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Hepatitis C - Overview, Clinical Features, Diagnosis and Management

by Kara Lau @ytk_lau

#HepatitisC #HCV #HepC #diagnosis #management
Hepatitis C - Overview ... , Clinical Features ... Lau @ytk_lau #HepatitisC
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Severe Acute Liver Injury ... - Ichemic hepatitis ... - Viral Hepatitis ... - Autoimmune hepatitis ... Acute #Causes #Differential
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
normal - Ischemic Hepatitis ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... normal - Chronic hepatitis ... transaminitis #differential
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
- Differential ... • Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... Pregnancy, Alcoholic Hepatitis ... Sepsis, Viral Hepatitis
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... of Alcoholic Hepatitis ... ) • Onset of jaundice ... Possible ischemic hepatitis ... diagnosis #Alcoholic #Hepatitis
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
Oftentimes total hepatitis ... commonly run in the clinical ... lab are total hepatitis ... Total hepatitis ... Diagnosis #HepB #HepatitisB
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... - Onset of jaundice ... Possible ischemic hepatitis ... #Autoimmune #Hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - Differential ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... Drug-induced liver injury ... #Tests #LFTs #Differential
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
- Differential ... Differential Diagnosis ... • Infections: Hepatitis ... #Differential # ... Transaminitis #LFTs #hepatitis
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hepatomegaly - Differential ... Infectious • Hepatitis ... • Alcoholic Hepatitis ... • Autoimmune Hepatitis ... • Drug Induced Hepatitis