27 results
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
of Severe Acute Liver ... Injury - Ichemic ... - Drug-Induced liver ... injury - Viral ... #Differential #Hepatology
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... #DrugInduced #Liver ... #Injury #Pathophysiology ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Alcohol-Associated Hepatitis ... Injury (DILI) ... Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... #gastroenterology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... Injury Transaminase ... , Toxic Hepatitis ... #Patterns #Liver ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... • Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... #Injury #Differential ... Acute #algorithm #hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
diagnosis of Alcoholic Hepatitis ... ) • Onset of jaundice ... ) or metabolic liver ... Possible drug-induced liver ... #AH #hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
of Autoimmune Hepatitis ... - Onset of jaundice ... ) or metabolic liver ... Possible drug-induced liver ... #Diagnosis #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injuryliver ... • Infections: Hepatitis ... #Diagnosis #hepatology ... Transaminitis #LFTs #hepatitis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... (DIC, ascites, jaundice ... Diagnosis: Viral Hepatitis ... #Pregnancy #hepatology ... diagnosis #management #pathophysiology