20 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
to Evaluate an Abnormal ... K Antagonists, Heparin ... to identify the cause ... ISNeducation #Abnormal ... #diagnosis #hematology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... Cholangitis #Jaundice ... #Differential # ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... PTT, Normal PT ... #PPT #PT #INR #Differential ... Diagnosis #Algorithm #Causes ... #Hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... amyloidosis #Abnormal ... #differential # ... hematology #coagulation
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Microangiopathy (TMA) - Differential ... hemoglobin/hemosiderin, Hepatic ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT ... normal • DAT
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... e.g. heparin ... Jcortesizaguirr #Abnormal ... #differential # ... hematology #coagulation
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Pruritus, Mild jaundice ... imaging: Normal ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Treat primary cause ... 100mg/dL) - Heparin ... INR < 2.3 - APTT ... Coagulation #diagnosis #causes ... treatment #management #hematology
Portal venous gas on hepatic ultrasound: A concerning finding in the critically ill patient that should
venous gas on hepatic ... reflection on the differential ... variety of other causes ... venousgas #ultrasound #hepatology ... #liver #pocus #
Etiologies of Hypoaldosteronism

Hyporeninemic Hypoaldosteronism (Low Renin, Low Aldosterone)
 - Diabetic Nephropathy 
 - NSAIDs
Non-Hyporeninemic Hypoaldosteronism (Normal
Inhibitors - Chronic heparin ... or High Renin, Normal ... Hypoaldosteronism #Differential ... #Aldosterone #Comparison ... #Table #Causes