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An Approach to Jaundice - Differential Diagnosis

- Increased Production (Prehepatic)
- Decreased Clearance (Intrahepatic + Posthepatic)

Dr. Eric
An Approach to Jaundice ... - Differential ... #Differential # ... Table #Causes #Intrahepatic ... Posthepatic #Diagnosis #Hepatology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... • Gilbert's Syndrome ... #Differential # ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... postoperative jaundice ... miscellaneous causes ... #unconjugated #differential ... #causes
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
onset RUQ pain, jaundice ... Supportive with treatment ... Hepatobiliary #hepatology ... #hepatitis #differential
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Transaminitis - Differential ... Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome ... #Diagnosis #causes ... #hepatology
Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
Dyspnea - Differential ... Cardiovascular Causes ... Hepatopulmonary syndrome ... Transverse myelitis • Hematology ... #dyspnea #sob #differential
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Non-lmmune: • HELLP Syndrome ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Causes of Ascites ... - Differential ... 2LmUODZ #Ascites #Differential ... Diagnosis #Algorithm #Hepatology ... #causes
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... Hyperviscosity #Syndrome ... #Causes #Differential ... #Diagnosis #Treatment
Causes of Pleural Effusion - Differential Diagnosis Algorithm
Transudate - Hydrostatic
 • Congestive heart failure
 • Constrictive
Causes of Pleural ... Effusion - Differential ... • Nephrotic syndrome ... Diagnosis #Algorithm #Hepatology ... #causes