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diagnosis hematology management algorithm anemia lymphocytic myelodysplastic treatment cancer classification comparison disorders erythematosus hemeonc hodgkins lupus lymphoma lymphomas lymphoproliferative myelodysplasia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... ALL Symptoms: ... • Age: 60-80 Clonal ... ) CLL Symptoms: ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... aplasia • ITP ... #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... cytometry → >500/uL clonal ... Lauren Banaszak, MD ... #Leukemia #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... Consider stem cell ... Can progress to MDS ... or acute leukemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... transformation to acute leukemia ... Allogeneic stem cell ... Management #treatment #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
virus (EBV) • Leukemia ... Hypocellular/Hypoplastic MDS ... • Improve the symptoms ... #Anemia #oncology ... #hematology #diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
involved) • No leukemic ... involvement Differential ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Causes • Anemia • Aplastic ... Marrow Failure • Chronic ... blood count with differential ... #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders - Differential ... pattern of spread, B symptoms ... Treated Like Acute Leukemias ... - Amy Chung, MD ... pathophysiology #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Induced Lupus: • Symptoms ... with Lupus: • Chronic ... Hodgkin lymphoma and leukemia
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