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diagnosis differential hematology algorithm clinical causes management microscopy blood pathology workup symptoms signs pathophysiology hemolytic nephrology neurology path bloodsmear cardiology
Sickle cell anemia and Howell Jolly bodies (nuclear remnants). - Dr. Abubaker Elshaikh @ElshaikhMD #SickleCell #HowellJolly #Body #Bodies
Sickle cell anemia ... and Howell Jolly ... Pathology #Hematology #Smear
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
peripheral blood smears ... in sickle cell anemia ... found in hemolytic anemia ... . pernicious anemia ... BloodSmear #Blood #Smear
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
photo are a Howell-Jolly ... with hemolytic anemias ... BloodSmear #Blood #Smear
Post-splenectomy blood smear demonstrating Howell-Jolly bodies and target cells. #Clinical #Pathology #BloodSmear #HowellJollyBodies #TargetCells #Splenectomy #Asplenic
Post-splenectomy blood smear ... demonstrating Howell-Jolly
Megaloblastic Anemia vs Normal Peripheral Smear #Megaloblastic #Anemia #Peripheral #Smear #Comparison #Clinical #Hypersegmented #Neutrophil
Megaloblastic Anemia ... Normal Peripheral Smear ... Megaloblastic #Anemia ... #Peripheral #Smear
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Abnormal peripheral smear ... Autoimmune Hemolytic Anemias ... #Hemolytic #Anemias
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood Smear ... Megaloblastic Anemia ... Microangiopathic hemolytic anemia ... Autoimmune hemolytic anemia ... Peripheral #Blood #Smear
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Associations • Howell Jolly ... Severe hemolytic anemia ... Sideroblastic anemia ... , Hemolytic anemia
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic Anemia ... or negative - Smear ... C3 positive - Smear ... Autoimmune #Hemolytic #Anemia
Dacrocytes (tear drop cells) Other poikilocytes resemble a pear or teardrop. The narrow, tapered end may be
metaplasia, pernicious anemia ... some hemolytic anemias ... BloodSmear #Blood #Smear
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