58 results
Paget's Disease of Bone

 • Characterized by an ↑ rate of bone turnover with both excessive
of Bone • Characterized ... and formation of bone ... • Caused by ( ... more (polystotic) bones ... pelvis, and long bones
Perianal Crohn's Disease - IBD Algorithm

 • 5-40% w perianal fistula
 • ↑ risk if colonic
Perianal Crohn's Disease ... - IBD Algorithm ... medical therapy • Chronic ... #IBDAlgorithm # ... IBD #Algorithm #
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... - Celiac - IBD ... • Chronic liver ... or kidney disease
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... Generally affects long bones ... BrighamChiefs #Bone ... Pain #SickleCell #Disease
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... excessive bone ... MSK • Deformed bones ... Lytic lesions make bones ... of middle ear bones
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Differential Diagnosis Algorithm ... Tumours - See Bone ... - Secondary to Chronic ... • Bone Marrow ... #Orthopedics #Causes
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Chemotherapy • Bone ... Disease • GI ... Celiac, IBD) • ... Chronic UTI) • ... endocrinology #causes
Hand X-Ray Anatomy and Interpretation Checklist
1. Soft tissues - Look carefully at the soft tissue over
tissue over all the bones ... Bones - All the ... bones of the hand ... in between the bones ... to the carpal bones
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... - Bone symptoms