135 results
Paget's Disease of Bone

 • Characterized by an ↑ rate of bone turnover with both excessive
by an ↑ rate of bone ... • Caused by ( ... more (polystotic) bones ... pelvis, and long bones ... #Bone #diagnosis
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... Generally affects long bones ... BrighamChiefs #Bone ... #differential #diagnosis
Dermatologic Extraintestinal Manifestations in IBD - IBD Algorithm

Erythema Nodosum
Pyoderma Gangrenosum
Metastatic Crohn's Disease
Sweet Syndrome
EBA

Dr. Wade Billings @wabillin

#Dermatologic
- IBD Algorithm ... Metastatic Crohn's Disease ... Manifestations #EIM #IBDAlgorithm ... #IBD #Algorithm ... #dermatology #diagnosis
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... MSK • Deformed bones ... Lytic lesions make bones ... of middle ear bones ... pathophysiology #diagnosis
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... Most cases diagnosed ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Algorithm ALP ... stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... - Bone symptoms
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
- Differential Diagnosis ... Algorithm Elevated ... Granulomatous Disease ... Miscellaneous - Bone ... #Algorithm #causes
Hand X-Ray Anatomy and Interpretation Checklist
1. Soft tissues - Look carefully at the soft tissue over
tissue over all the bones ... Bones - All the ... bones of the hand ... in between the bones ... to the carpal bones
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... - Celiac - IBD ... liver or kidney disease ... signs #symptoms #diagnosis
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... inflammation of the bones ... • Bone and joint ... Rule out other causes ... osteoarticular and skin disease