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diagnosis differential hematology management syndrome workup classification clinical covid19 endocrinology hepatology hypomagnesemia infectiousdiseases magnesium oncology pancytopenia alkaline alp amyloid amyloidosis
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... MSK • Deformed bones ... Lytic lesions make bones ... Nerve Palsies • Disordered ... of middle ear bones
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia Low ... Granulomatous Disease ... Miscellaneous - Bone ... Hyperthyroid, Bony ... #causes #endocrinology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Production - Flow ... cytometry, Bone ... Alcoholism Bone ... • Congenital bone ... Metastatic Disease
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
of bone, joint, ... inflammation of the bones ... • Bone and joint ... Rule out other causes ... osteoarticular and skin disease
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Production - Flow ... cytometry, Bone ... Alcoholism Bone ... • Congenital bone ... Metastatic Disease
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm Tumours - See Bone Lesions Scheme Paget's Disease -
Differential Diagnosis Algorithm ... Tumours - See Bone ... • Bone Marrow ... Disorder • Endocrinopathy ... #Orthopedics #Causes
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
Chronic diarrhea / IBD ... Pancreatitis - Hungry bones ... Differential #Diagnosis #Low ... Classification #Causes
Bilateral B-Lines in case of Pneumonia on Lung POCUS Young healthy pt with fever/dyspnea. POCUS lung exam
Bilateral B-Lines in case ... POCUS lung exam done ... interstitial lung disease ... POCUS shows a lot ... Robert Jones @RJonesSonoEM
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 Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... megakaryocytic Bone ... Aplastic Anemia • Bone ... the blood and bone ... blood smear • Bone
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