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diagnosis differential management orthopedics hemophagocytic hepatology hlh jointpain lymphohistiocytosis rheumatology signs symptoms syndrome alkaline alp anemia ascorbicacid chondrocalcinosis chronic cirrhosis
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... formation MSK ... • Deformed bones ... Lytic lesions make bones ... of middle ear bones
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm Tumours - See Bone Lesions Scheme Paget's Disease -
Differential Diagnosis Algorithm ... Tumours - See Bone ... • Bone Marrow ... Fractures #Pathologic #MSK ... #Orthopedics #Causes
Vascular Joint Pain - Differential Diagnosis Algorithm - Constant Pain (Ischemia) - Acute Onset -
Peripheral Vascular Disease ... fractured long bone ... • Dislocated Bone ... Vascular #JointPain #MSK ... #Orthopedics #Causes
Chronic Joint Pain - Differential Diagnosis Algorithm Intra-Articular - Bone • Stress
Intra-Articular - Bone ... Osgood-Schlatter Disease ... Ganglion Cyst - Bone ... Intraarticular #MSK ... #Orthopedics #Causes
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... inflammation of the bones ... • Bone and joint ... Rule out other causes ... osteoarticular and skin disease
Osgood-Schlatter Disease - MSK Radiology Imaging Findings: • Infrapatellar fat-pad edema with loss of the patellar tendon
- MSK Radiology ... fragmentation and mild ... bone marrow edema ... marrow edema and bony ... Radiology #diagnosis #msk
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... • Cushing's Disease ... Chemotherapy • Bone ... Celiac, IBD) • ... endocrinology #causes
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... cytokines (TNFa,lL1, IL6 ... , Biological + Bone ... /ml, ↑ LDH • Bone ... • Autoimmune diseases
Bone Deformity / Limp - Differential Diagnosis Algorithm Infection • Septic Arthritis • Cortical Hypertrophy •
Bone Deformity / ... Differential Diagnosis Algorithm ... Arthritis Other Causes ... • Dwarfism #Bone ... Deformity #Limp #MSK
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