45 results
Paget's Disease of Bone

 • Characterized by an ↑ rate of bone turnover with both excessive
of Bone • Characterized ... and formation of bone ... • Caused by ( ... more (polystotic) bones ... pelvis, and long bones
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... formation MSK ... • Deformed bones ... Lytic lesions make bones ... of middle ear bones
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... Generally affects long bones ... BrighamChiefs #Bone ... Pain #SickleCell #Disease
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Differential Diagnosis Algorithm ... Tumours - See Bone ... • Bone Marrow ... Fractures #Pathologic #MSK ... #Orthopedics #Causes
Bone Lesion on X-Ray - Differential Diagnosis Algorithm 
Exostotic
 • Osteochondroma
Asymptomatic &/or Non-Active Bone Scam
 •
Bone Lesion on X-Ray ... /or Non-Active Bone ... • Unicameral Bone ... BoneLesion #XRay #MSK ... #Orthopedics #Causes
Primary Bone Tumors - Differential Diagnosis Algorithm 

Metastatic - Most common tumour in adults
 - Breast
Primary Bone Tumors ... • Aneurysmal Bone ... Histiocytoma #Primary #Bone ... Tumours #MSK #Differential ... #Orthopedics #Causes
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Hand X-Ray Anatomy and Interpretation Checklist
1. Soft tissues - Look carefully at the soft tissue over
tissue over all the bones ... Bones - All the ... bones of the hand ... in between the bones ... to the carpal bones
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... - Bone symptoms
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Differential Diagnosis Algorithm ... Granulomatous Disease ... Miscellaneous - Bone ... Hyperthyroid, Bony ... #causes #endocrinology