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diagnosis differential orthopedics alp hepatology jointpain phosphatase amyloid amyloidosis chronic clinical complications deformity dermatology elevation endocrinology extremity fractures fragility hyophosphatasia
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... - Bone symptoms
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm Tumours - See Bone Lesions Scheme Paget's Disease -
Tumours - See Bone ... Pelvis - Positive Alkaline ... • Bone Marrow ... Fractures #Pathologic #MSK ... #Orthopedics #Causes
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... formation MSK ... • Deformed bones ... Lytic lesions make bones ... of middle ear bones
Vascular Joint Pain - Differential Diagnosis Algorithm - Constant Pain (Ischemia) - Acute Onset -
Peripheral Vascular Disease ... fractured long bone ... • Dislocated Bone ... Vascular #JointPain #MSK ... #Orthopedics #Causes
Chronic Joint Pain - Differential Diagnosis Algorithm Intra-Articular - Bone • Stress
Intra-Articular - Bone ... Osgood-Schlatter Disease ... Ganglion Cyst - Bone ... Intraarticular #MSK ... #Orthopedics #Causes
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... inflammation of the bones ... • Bone and joint ... Rule out other causes ... osteoarticular and skin disease
Osgood-Schlatter Disease - MSK Radiology Imaging Findings: • Infrapatellar fat-pad edema with loss of the patellar tendon
- MSK Radiology ... fragmentation and mild ... bone marrow edema ... marrow edema and bony ... Radiology #diagnosis #msk
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... • Cushing's Disease ... Chemotherapy • Bone ... Celiac, IBD) • ... endocrinology #causes
Bone Deformity / Limp - Differential Diagnosis Algorithm Infection • Septic Arthritis • Cortical Hypertrophy •
Bone Deformity / ... Differential Diagnosis Algorithm ... Arthritis Other Causes ... • Dwarfism #Bone ... Deformity #Limp #MSK
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