67 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Exogenous (KCL ... MunerMohamed1 #hyperkalemia ... differential #diagnosis #pathophysiology ... #pharmacology #
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Aldosterone Release: ACE ... happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology #
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
S - Shock H - Hyperkalemia ... ) BRASH Treatment ... • Aggressive treatment ... of hyperkalemia ... diagnosis #management #pathophysiology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
spontaneously (before any treatments ... leukemia (both ALL ... malignancies Treatments ... 6L/day) • For hyperkalemia ... otherwise treat with "hyperkalemia
Initial treatment of renal bone disease and cinacalcet for secondary hyperparathyroidism
Phosphate binders reduce hyperphosphataemia and hyperparathyroidism.
Initial treatment ... the first-line treatments ... #Pharmacology #Pathophysiology
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
Hydroxyurea - Pathophysiology ... vs. 1) • Fewer ACS ... Benefits #SickleCell #pathophysiology ... #pharmacology
Emergency Therapy of Hyperkalemia
Therapy - Dose and Route - Onset of Action - Duration of Effect
Emergency Therapy of Hyperkalemia ... Hemodialysis #Hyperkalemia ... #management #pharmacology ... #table #treatment
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
INDICATION: Treatment ... of Hyperkalemia ... who have chronic hyperkalemia ... ACE inhibitors, ... #Pharmacology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... organ damage • Treatment ... Lysis Syndrome: • Pathophysiology ... hydration - Hyperkalemia
Medications Used in Hypertensive Emergencies
Vasodilators: Hydralazine, Nitroglycerin, Sodium nitroprusside 
Calcium Channel Blockers: Clevidipine, Nicardipine
ß-Blockers: Esmolol, Labetalol,
Labetalol, Metoprolol ACE ... Medications #Management #Treatment ... #Pharmacology #