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diagnosis clinical glomerulonephritis electronmicroscopy sem algorithm differential membranous glomerular proteinuria causes classification comparison diseases glomerulus hemepath injury mastocytosis microscopy mpgn
This image shows acellular scanning EM showing glomerular basement membrane duplication at high power in a
acellular scanning EM ... arkanalabs #GBM ... #membranoproliferative ... SEM #clinical #nephrology ... #pathology
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 Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative ... Mesangiocapillary GN ... immune deposits on EM ... malignant HTN #Membranoproliferative ... #nephrology #diagnosis
Stage III Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM from a biopsy with membranous
acellular scanning EM ... more extensive GBM ... surface of reticular GBM ... #stage3 #GBM #ElectronMicroscopy ... #pathology
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 Stage II Membranous Glomerulonephritis on Electron Microscopy This eyeSCANdy image shows acellular scanning EM of a glomerulus
acellular scanning EM ... appearance of GBM ... glomerulonephritis #MGN ... #stage2 #GBM #ElectronMicroscopy ... #pathology
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 Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
nephropathy • Membranoproliferative ... GN • Mesangial ... proliferative • Anti-GBM ... Post-infectious GN ... #Proteinuria #Nephrology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
post-infectious GN ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... staining on IF • No EM ... Differential #Diagnosis #Nephrology
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
acellular scanning EM ... completely bridged GBM ... glomerulonephritis #glomerulus #MGN ... SEM #clinical #nephrology ... #pathology
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 Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
Electron Microscopy (EM ... Post-infectious GN ... RPGN • Anti-GBM ... glomerular #diseases #nephrology ... #pathology #comparison
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Cytomegalovirus; GBM ... basement membrane; GN ... atypical HUS; MPGN ... = membranoproliferative ... nephrotic #syndrome #nephrology
Guide to systemic mastocytosis Criteria for diagnosis: at least 1 major and 1 minor or 3 minor
aggregates) in BM ... are atypical on BM ... release • MCs in BM ... Hypercellular BM ... mastocytosis #hemepath #pathology
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