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diagnosis hepatology management chemistry differential hematology acutephasereactants alkphos arterial astalt bilirubin causes comparison degenerative dic disease disseminated embolism fungal infections
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... dysfunction (25%) • Hepatic ... venipuncture sites Laboratory ... DIC • Severe Liver ... 100mg/dL) - Heparin
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Interpretation of LFTs ... • Albumin • Coagulation ... replaced by non-hepatic ... transaminitis #LFTs
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... In liver, 80% of ... Chemistry #Tests #Laboratory ... Bilirubin #Hepatology #Pathophysiology ... #Diagnosis #LFTs
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Syndrome, Ischemic Liver ... cardiac valves (septic ... Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... Venous #Arterial #pathophysiology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Diseases • Septic ... more time for the laboratory ... profile, including liver ... function tests (LFTs ... #laboratory #workup
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
with motion • Lots ... in Rheumatoid arthritis ... Stiffness is short-lived ... JointPain #Diagnosis #pathophysiology
Acute-phase Reactants Synthesized in the Liver Positive acute-phase reactants (concentrations increase with acute inflammation) - Immune-related
Synthesized in the Liver ... Ceruloplasmin - Coagulation ... #Synthesized #Liver ... Synthesis #Hepatology #pathophysiology ... #Laboratory
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... Extrapulmonary: ankle arthritis ... heart (2-5%), liver ... (pain/abnormal LFT
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Mississippi and Ohio River ... Aspergillosis Pathophysiology ... Isolated fever • Septic ... • Meningitis, septic ... arthritis, and
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