14 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... more specific for hepatic ... • R value = (ALT ... #Enzymes #LFTs ... Transaminitis #diagnosis #differential
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... Calculate R-Value ... Idiosyncratic #differential ... #Diagnosis #Management
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... R-value: Serum ... replaced by non-hepatic ... chemistry #diagnosis #differential ... transaminitis #LFTs
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... >10 mmHg - clinically ... hepatorenal syndrome Clues ... sarcoidosis) • Liver ... metastasis • Fatty liver
Echinococcal Cysts in the Liver- The physical examination revealed hepatomegaly with a palpable hepatic mass. Laboratory
with a palpable hepatic ... Laboratory tests ... blood (normal value ... #clinical #NEJM ... #hepatic #radiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... venipuncture sites Laboratory ... DIC • Severe Liver ... 100mg/dL) - Heparin ... causes #treatment #management
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... RBCs, muscle, liver ... - Prosthetic valves ... lung injuries Hepatic ... #diagnosis #Laboratory
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... of lactate as a clinical ... to bolus these values ... - assess other laboratory ... Acidosis #Elevation #Differential
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Diseases • Septic ... more time for the laboratory ... profile, including liver ... function tests (LFTs ... ANA and RF (if clinical
Shock Overview
A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death Common Clinical ... AI, thyroid dz liver ... Failure, Severe Valve ... Classification #diagnosis #management ... #criticalcare #differential