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hepatology differential algorithm gastroenterology injury rheumatology transaminitis treatment disease signs summary aclf acute arthritis ascites biliary chemistry cholangitis classification complications
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... • NAFLD • Cirrhosis ... • Chronic Viral ... ) • Non-hepatic
End Stage Liver Disease (Cirrhosis) - Complications • Ascites • Esophageal Varices • Hepatic
End Stage Liver ... Disease (Cirrhosis ... Esophageal Varices • Hepatic ... #Cirrhosis #Complications ... #diagnosis #management
Ascites - Differential Diagnosis Chronic liver disease (cirrhosis or chronic hepatitis) - 80% Underlying malignancy - 10% Congestive heart
- Differential Diagnosis ... Chronic liver disease ... (cirrhosis or chronic ... failure - 3-5% Cirrhosis ... Disease, Fulminant Hepatic
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... #ACLF #Acute #Chronic ... #Cirrhosis #Hepatology ... #diagnosis
Approach to the Hospitalized Patient with Cirrhosis 1) Recognize and Manage Decompensation • Ascites • Variceal Bleeding
Hospitalized Patient with Cirrhosis ... Variceal Bleeding • Hepatic ... Portosystemic Shunt • Liver ... #diagnosis #treatment ... #management
Clinical Examination for Liver and Biliary Diseases 1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Examination for Liver ... a patient with chronic ... #physicalexam #cirrhosis ... #liver #disease ... #signs #diagnosis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... Injury #hepatology #LFTs ... #differential #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... replaced by non-hepatic ... hepatitis: < 1 • Cirrhosis ... #chemistry #diagnosis ... transaminitis #LFTs
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... #differential #Diagnosis ... #Management #gastroenterology
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
PSC) PSC is a chronic ... intra- and extra-hepatic ... asymptomatic at diagnosis ... disease management ... #management #summary
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