124 results
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... diagnosed annually in US ... risk-stratification • Risks: infection ... #treatment #hematology
IDSA Algorithm for the Management of Purulent skin and soft tissue infections (SSTIs). 
Mild infection: for
Algorithm for the Management ... incision and drainage plus ... 12 000 or <400 cells ... or those with clinical ... SSTIs #Algorithm #Management
A non-subtle example of true Sezary syndrome.  Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... #Cells #Clinical ... Smear #Microscopy #Hematology
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
Non-HCV infectious ... Diagnosis, causes and management ... cryoglobulinemia vasculitis Clinical ... Cryoglobulinemia #Vasculitis #Rheumatology ... Cryoglobulinemic #Diagnosis #Management
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
DIC, TTP, HUS) ... anemia Sickled red cells ... disease Bite cells ... Smear #Analysis #hematology ... interpretation #clinical
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia Clinical ... Neutropenia - recurrent infections ... Idiopathic • Infections ... Anemia #oncology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 T cells ... accumulation of clinical ... Assessment • Clinical ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Non-lmmune: • HELLP Syndrome ... • TTP/HUS • ... Vasculitis • Infection ... Algorithm #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
SLE) - Viral infections ... Kasabach-Merritt syndrome ... APLS • Acute Infectious ... Gardner-Diamond syndrome ... #rheumatology #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... (HUS) • Other ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections