11 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Algorithm for Investigation ... of Abnormal Coagulation ... DrEricStrong #Algorithm ... #Coagulation #Abnormal ... #APTT #Laboratory
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
on Coagulation ... Tests PT / INR, aPTT ... Anticoagulation #Testing ... #Diagnosis #Laboratory ... #Effects
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Prolonged PT (INR), Normal ... PTT, Normal PT ... , Normal PT (INR ... Differential #Diagnosis #Algorithm ... Causes #Hematology #coagulation
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Congenital intrinsic coagulation ... Supratherapeutic warfarin effect ... intravascular coagulation ... Jcortesizaguirr #Abnormal
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT/PTT ... venipuncture sites Laboratory ... Thrombocytopenia - Normal ... INR < 2.3 - APTT ... < 1.5 x normal
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation ... aggregation PT, aPTT ... consumption of coagulation ... Intravascular #Coagulation ... diagnosis #hematology #laboratory
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... fibrinogen levels, and testing
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... Supratherapeutic warfarin effect ... amyloidosis #Abnormal ... differential #hematology #coagulation
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... unconjugated bilirubin - Defects ... gluconeogenesis in the fasting ... Hepatic #Hepatology #Laboratory ... #Diagnosis #Testing
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
ristocetin • Normal ... platelet, PT, PTT ... with qualitative defects ... considered first-line testing ... • Usually normal