12 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus Nephritis ... • Limited to Kidney ... #differential #diagnosis ... #algorithm #rheumatology
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
broad - Advanced kidney ... tubulointerstitial nephritis ... syndrome ("Maltese ... #Differential #Microscopy ... #Diagnosis #Nephrology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Differential Diagnosis ... Polyarteritis nodosa • Microscopic ... • Goodpasture syndrome ... #rheumatology
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... tubular necrosis (causes ... : sepsis, meds, ... Acute interstitial nephritis ... Classification #diagnosis
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... acute and chronic kidney ... suggestive of nephrotic ... sydnrome • Pigment ... interpretation #diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... and Differential Diagnosis ... dipstick, urine microscopy ... osmolarity If cause ... • Interstitial nephritis
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... Kidney Injury (AKI ... • Hepatorenal syndromes ... polyangiitis /microscopic ... Acute Interstitial Nephritis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
PR3-ANCA): • Microscopic ... > PR3 60% • GPA ... tract, and often causes ... , EGPA, microscopic ... #rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Labs/Diagnosis: ... , EGPA, microscopic ... classification #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
myalgia, serositis, Kidney ... ulcers, Lupus nephritis ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management