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differential management lad lymphadenopathy diffuse hemophagocytic hlh localized lymphohistiocytosis cell child essential et gammopathies glomerulonephritis hemeonc limping mgus monoclonal multiplemyeloma
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... - Differential Diagnosis ... ) #Diffuse #Focal ... #Algorithm #Causes ... #Hematology #Oncology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... Algorithm Cervical ... #Localized #Focal ... #Algorithm #Causes ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Algorithm Spurious ... Artifact (redo CBC ... #Algorithm #Causes ... #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Algorithm Reactive ... #Algorithm #Causes ... #Hematology #Oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Cr >2 mg/dL or CC ... ratio ≥100 • >1 focal ... Causes of false- ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
FLAGS - In all cases ... Injury - Follow local ... cell disease Rheumatology ... #Limping #NWB #Algorithm ... Peds #Pediatrics #Diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... #differential #diagnosis ... #algorithm #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... Auto-amplification loop Diagnosis ... Drugs, Unknown cause ... treatment #summary #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
lacrimal glands: • Focal ... Hypocomplementemia • Can cause ... /aggregate) of CD4 ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... : On the CBC, ... • Treatment algorithms ... Thrombocythemia #ET #hematology ... #hematology
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