9 results
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Pruritus - Generalized ... Hyperthyroidism CBC ... Myelodisplastic syndrome ... secondary #systemic #generalized ... #dermatology #Differential
DRESS Syndrome vs SJS/TEN
DRESS
 • Latency: 2-8 weeks
 • Rash: Morbilliform
 • Mucosal involvement: 50% have
DRESS Syndrome vs ... with erosions • CBC ... Rash: Painful erythematous ... SCVMCMed #DRESS #Syndrome ... comparison #table #dermatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... vein thrombosis Hematologic ... titers > 1:80 • CBC
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus erythematosus ... Hepatosplenomegaly and generalized ... systemic lupus erythematosus ... Diagnosis #Management #Hematology ... #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Systemic #Lupus #Erythematosus ... CNS #neurology #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ischemia - Skin: erythematous ... • Cogan Syndrome ... systemic lupus erythematosus ... Lab Tests: • CBC ... differential #diagnosis #rheumatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
Hyperthyroidism CBC ... Myelodisplastic syndrome ... secondary #systemic #generalized ... #dermatology #Differential
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
TAFRO TAFRO syndrome ... nodes TAFRO syndrome ... systemic lupus erythematosus ... cell lymphoma Pathophysiology ... diagnosis #management #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... patients with the HLH syndrome ... Pathophysiology ... of NK cells and CD8 ... Diagnosis #Management #Hematology