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diagnosis management rheumatology hemophagocytic hepatology hlh inflammatory lymphohistiocytosis reconstitution aids chronic cll differential hemeonc hepatopulmonary hepatorenal hps hrs leukemia lymphocytic
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology Risk factors: - Low CD4 count - Disseminated OI -
Inflammatory Syndrome ... (IRIS) - Pathophysiology ... factors: - Low CD4 ... duration or OI treatment ... #IRIS #Pathophysiology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Immune Reconstitution ... Inflammatory Syndrome ... progression of cirrhosis ... #IRIS #Immune ... #Inflammatory #Syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... that disrupts immune ... Others: Cellular immune ... Unknown cause Treatment
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune ... microglobulin Treatment ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... workup #oncology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... /aggregate) of CD4 ... primary biliary cirrhosis ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... activation of the immune ... Pathophysiology ... of NK cells and CD8 ... Diagnosis #Management #Hematology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
abnormalities PATHOPHYSIOLOGY ... • Stigmata of cirrhosis ... the left heart TREATMENT ... #cirrhosis #diagnosis ... #hepatology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
TAFRO TAFRO syndrome ... IGG4 - Hepatic cirrhosis ... cell lymphoma Pathophysiology ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... liver disease: cirrhosis ... Pathophysiology: ... Treatment Overview ... #Hepatorenal #Syndrome
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