25 results
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology
Risk factors:
 - Low CD4 count
 - Disseminated OI
 -
Syndrome (IRIS) - Pathophysiology ... factors: - Low CD4 ... duration or OI treatment ... Syndrome #IRIS #Pathophysiology ... #AIDS
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Syndromes: • Pauci-Immune ... Cryoglobulinemia) • Immune ... Investigations • Labs: CBC ... differential #diagnosis #nephrology
Cytomegalovirus (CMV) in HIV-AIDS Patients
Cytomegalovirus (CMV): double-stranded DNA virus, herpesvirus family.
CMV infection: virus isolation or detection
Cytomegalovirus (CMV) in HIV-AIDS ... patient with HIV and CD4 ... 50 or less: • Neurologic ... of blindness in AIDS ... Pancreatitis • Pulmonary
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
Infection in HIV / AIDS ... Antimicrobial treatment ... required until immune ... status, and focal neurologic ... differential #diagnosis #AIDS
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Immune Reconstitution ... of HIV/AIDS patients ... be present: • AIDS ... Lymphadenitis, pulmonary ... lymphadenitis, pulmonary
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... : 33% • Treatment ... transfusion • Pathophysiology ... , and CXR with pulmonary ... : No • Treatment
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Summary Acute AIDP ... Guillain-Barre Pathophysiology ... : • Immune response ... Treatment: • Plasmapheresis ... #neurology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... that disrupts immune ... Others: Cellular immune ... Unknown cause Treatment
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
impaired cellular immune ... , Advanced HIV/AIDS ... presentations: • Pulmonary ... this morphology Treatment ... Diagnosis #Management #treatment
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Progression: (+) Immune ... rest LTBI (-) Immune ... Tuberculosis Treatment ... Initiating Treatment