10 results
Bullous Pemphigoid - Diagnosis and Management Summary
Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Bullous Pemphigoid ... Management Summary Pathophysiology ... dermis Clinical Signs ... not feasible CMC ... Diagnosis #Management #dermatology
Nikolsky's Sign in Toxic Epidermal Necrolysis (TEN)

Nikolsky's sign is a clinical dermatological sign which is present
Nikolsky's Sign ... Stevens-Johnson Syndrome ... Staphylococcal scalded skin syndrome ... is present) and bullous ... #TEN #Dermatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
herpetiformis • Bullous ... Hyperthyroidism CBC ... Myelodisplastic syndrome ... #generalized #dermatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology ... #hematology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Sweet Syndrome ... Episcleritis Signs ... - CBC may also ... #diagnosis #dermatology ... #oncology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... : • Pathophysiology ... diagnosis #management #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Cr >2 mg/dL or CC ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Differentiation #Syndrome ... diagnosis #management #hematology ... #oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
reticularis, ulcers, and bullous ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... purpura: strong sign ... Lab Tests: • CBC
Conduct Disorder (CD): Pathogenesis and clinical findings
 - Must have >3 symptoms present in the past
Conduct Disorder (CD ... However, CD may ... sexual activity • Bullies ... BehavioralDisorder #Pathophysiology ... diagnosis #symptoms #signs