13 results
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... regeneration, diffuse CD8 ... primarily deltoids and hip ... PM #Diagnosis #Pathophysiology ... #Signs #Symptoms
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... Infection (Viral- HIV ... (polymyositis/Dermatomyositis ... ) AKI - Pathophysiology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Sweet Syndrome ... Episcleritis Signs ... multiforme - Dermatomyositis ... - CBC may also ... #dermatology #oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Lymphocytosis on CBC ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... Lack of UMN/LMN signs ... parainfluenza, Coxsackie, HIV ... Muscle Biopsy: Dermatomyositis
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Type IV Hypersensitivity ... -> Particular CD4 ... Stevens-Johnson Syndrome ... Allergy #Immunology #pathophysiology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
impairment • HIV ... dementia Pathophysiology ... : HIV frequently ... The clinical syndrome ... and with low CD4
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Infections in HIV ... Pneumonia: • 3 syndromes ... • CT: Halo sign ... macrophages in HIV ... of a "flu-like syndrome
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... • Steroids: IV ... Differentiation #Syndrome ... management #hematology #oncology
Supracondylar Elbow Fracture
• Most common elbow fracture in children, peak age 5-7 
• When looking at
anterior sail sign ... can't make A-OK sign ... ), compartment syndrome ... Disposition: Type l, DC ... week; Types II-IV